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KMID : 0363420180320020043
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Journal of Korean Oriental Pediatrics
2018 Volume.32 No. 2 p.43 ~ p.63
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Review of Clinical Researches for Herbal Medicine Treatment on Nocturnal Enuresis in Children
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Shin Hye-Jin
Lee Bo-Ram
Lee Ji-Hong
Chang Gyu-Tae
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Abstract
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Objectives: The purpose of this study is to evaluate the efficacy and safety of herbal medication for the treatment of nocturnal enuresis in children by analyzing randomized controlled trials conducted in China.
Methods: We searched literatures from China National Knowledge Infrastructure published up to 19 January, 2018. Selected literatures were collected and analyzed in order of publication year, and then demographic information, treatment method, duration of illness, duration of treatment, follow-up period, outcome measurement and adverse events.
Results: A total of 34 studies were selected for the analysis. In most studies, the total efficacy of the treatment group was reported to be higher than that of the control group, and the recurrence rate and complete cure rate were also found to be more effective in the herbal medicine treatment group. The most frequently used medical herb was Alpiniae Fructus (益智仁), and the use of medical herbs belong to tonifying yang (補陽藥), tonifying qi (補氣藥), and astringing essence strengthening collapse medicine (澁精縮尿止帶藥) were relatively high. The adverse events rate for the herbal medicine treatment group were significantly lower than those in the Western medicine treatment group.
Conclusions: This study showed that a herbal medicine treatment can be effective and safe option for treating pediatric nocturnal enuresis. However, additional well-designed clinical studies need to be performed to establish a basis.
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KEYWORD
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Nocturnal enuresis , Herbal medicine , Randomized controlled trial , Review
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